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CARDIO PROTECT

Protection for your heart
Rs. 690.00

For 60 vegetarian capsules.

Inclusive of taxes & shipping
FREE Delivery on order over Rs.500/-
COD Available|Secure Payment

Cardio Protect contains our pure and powerful pomegranate extract with antioxidant properties that help in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure. Clinical studies show that pomegranate’s ellagi tannins promote the antioxidant health of the heart and help fight cell damaging free radicals.

Core Benefits

  • Promotes the antioxidant health of the heart and helps fight cell damaging free radicals
  • Slows down the progression of arterial plaque built up and, in certain cases, may even reverse it
  • Helps in reducing blood pressure by reducing stress-induced vasoconstriction (narrowing) of the blood vessels
  • Prevents the oxidative destruction of nitric oxide, ensuring its availability for its essential vessel-protective functions

Product Details

Curegarden Natural Cardio Protect: The extraordinary natural protector of heart health

Cardio Protect is a pure and extremely powerful antioxidant that naturally improves cardiovascular health and helps preserve cardiovascular well-being even in healthy people. It naturally protects the health of the heart by assisting in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure.

While pomegranate as a fruit has multiple health benefits, the real source of antioxidants are the hydrolysable tannins, especially the ellagi tannins. The ellagi tannins are not only water soluble but also the major contributors of antioxidant properties that give the fruit its health benefits. What makes Cardio Protect exceptional is the fact that it is composed of Curegarden’s unique pomegranate extract which has been standardized to contain the 100% absorbable ellagi tannins. As a result, the product has a high ORAC (oxygen radical absorbance capacity) value, which is a measure of the antioxidant capacity of a sample.

Cardio Protect is an adjunct therapy. Please consult your physician before use.

Pomegranate – the superfruit with significant cardiovascular benefits!

Pomegranate (Punica granatum) has garnered universal acclaim for its powerful antioxidant properties that make it so beneficial for cardiovascular health. It is one of the tastiest ways to make the heart healthy. In fact, studies have found pomegranate juice to have a higher antioxidant potential than even that of green tea or red wine. A wide range of polyphenols (plant chemicals) including tannins, flavonoids and anthocyanins have been found to be present in pomegranate. The hydrolyzable tannins (which include ellagi tannins and gallo tannins) in pomegranate account for 92% of its antioxidant activity. Ellagi tannins are polyphenols that are unique to pomegranate and are 100% water soluble. These are the key potent anti-oxidants that give pomegranate its therapeutic value.

Studies have shown that due to its strong antioxidant powers, pomegranate has the ability to slow down the build-up of arterial plaques, which leads to atherosclerosis. It also been shown to regulate blood pressure and thereby help in bringing about an overall improvement in the well being of the heart.

Applying Pomegranate’s benefits for the well being of the heart

One of the key underlying causes for atherosclerosis is endothelial dysfunction. The cells that line the blood vessels form the endothelieum. When they develop a defect, it results in impairing blood flow and also causes the accumulation of arterial plaque. Nitric oxide is one of the plays an essential role in protecting the endothelium. It is an important cellular signaling molecule and is involved in many physiological and pathological processes including vasodilation.

Studies have shown that with its strong antioxidant properties, pomegranate exerts its cardiovascular benefits by supporting nitric oxide activity. It protects nitric oxide from oxidative destruction thereby reversing the accumulation of atherogenic plaque.

The antioxidants in pomegranate play a key role in protecting the lipid peroxidation of LDL cholesterol, reducing carotid artery thickness, and lowering the pro-atherogenic effect on arterial walls. It has thus also been proved beneficial in reducing stress-induced vasoconstriction of the blood vessels, in addition to regulating blood pressure.

How it works

This formulation is a pure bioavailable form of pomegranate, which is a powerful antioxidant that improves cardiovascular health and preserves cardiovascular wellbeing even in healthy people. . It naturally protects the health of the heart by assisting in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure.

While pomegranate as a fruit has multiple health benefits, the real source of antioxidants are the hydrolysable tannins, especially the ellagi tannins. The ellagi tannins are not only water soluble but also the major contributors of antioxidant properties that give the fruit its health benefits. What makes Cardio Protect exceptional is the fact that it is composed of Curegarden’s unique pomegranate extract which has been standardized to contain the 100% absorbable ellagi tannins. As a result, the product has a high ORAC (oxygen radical absorbance capacity) value, which is a measure of the antioxidant capacity of a sample. Cardio Protect is an adjunct therapy. Please consult your physician before use.

Facts Sheet

Serving size:

400mg capsules containing:

Carbohydrate: 11.2mg; Protein: 10mg; Fat: 3.6mg; Energy value: 0.12 Kcal/capsule.

Ingredients:

Each 400mg capsule contains pomegranate extract :400 mg 

Recommended usage:

One capsule in the morning and one at night, after food. 

Net content:

60 vegetarian capsules. 

Directions:

Store in a cool and dry place. If pregnant or under medication, consult your health care practitioner before using. Keep out of reach of children.

Scientific Papers

Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.

Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram

Punblication : Clin Cancer Res 2006;12(13) July 1, 2006 http://clincancerres.aacrjournals.org/content/12/13/4018.full.pdf+html or http://clincancerres.aacrjournals.org/content/12/13/4018.long

The authors' primary intention was to determine the effects of pomegranate juice consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy. The study went on well without any serious adverse events reported and the treatment was well tolerated. Mean PSA doubling time significantly increased with treatment.

Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland

Navindra P. Seeram William J. Aronson , Yanjun Zhang , Susanne M. Henning , Aune Moro, Ru-po Lee, Maryam Sartippour , Diane M. Harris , Matthew Rettig , Marc A. Suchard ,Allan J. Pantuck , Arie Belldegrun and David Heber .

Publication : J. Agric. Food Chem. 2007, 55, 7732–7737 http://pubs.acs.org/doi/pdfplus/10.1021/jf071303g

Present study suggest the potential for pomegranate products to play a role in prostate cancer chemoprevention . Ellagic acid and several synthesized urolithins were shown to inhibit the growth of human prostate cancer cells in vitro

Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB- dependent mechanism.

Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A.

Publication : Mol Cancer Ther. 2008 Sep; 7(9): 2662–2671. http://mct.aacrjournals.org/content/7/9/2662.full.pdf+html

Dietary agents such as pomegranate extract (PE) have received increasing attention as potential agents to prevent the onset or progression of many malignancies, including prostate cancer. Dietary agents with preventive potential can be applied at various points in the natural and treated history of prostate cancer. For example, in addition to primary prevention, pomegranate consumption could potentially be used to prevent or delay clinical recurrences once patients experience biochemical recurrences after radical prostatectomy

Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.

Arshi Malik, Farrukh Afaq, Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, and Hasan Mukhtar

Publication: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8. Epub 2005 Sep 28 http://www.pnas.org/content/102/41/14813.full.pdf

The present findings suggest that the fruit pomegranate and its associated antioxidants may possess a strong potential for development as a chemo preventive and possibly therapeutic agent against prostate cancer. Prostate cancer is the most common invasive malignancy and the second leading cause of cancer- related deaths among U.S. males,with a similar trend in many other countries. One approach to control this malignancy is its prevention through the use of agents present in diet consumed by humans. Pomegranate possesses strong antioxidant and anti-inflammatory properties.

The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

Kroeger N, Belldegrun AS, Pantuck AJ.

Publication: Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013), http://www.hindawi.com/journals/ecam/2013/701434/

The authors reports that the most striking evidence for the biological activity of pomegranate extracts is in controlling prostate cancer cells. In vivo and in vitro studies have shown that pomegranate extracts are capable of inhibiting tumor cell proliferation, migration, and invasion, while also inducing apoptosis.

Studies on Antioxidant Activity of Pomegranate (Punica granatum) Peel Extract Using in Vivo Models.

Kotamballi N. Chidambara Murthy,Guddadarangavvahally.K. Jayaprakasha,Ravendra P. Singh

Publication J. Agric. Food Chem. https://goo.gl/Ctlmwl

The results of the present work reiterate that the pomegranate peel extract is capable of enhancing or maintaining the activity of hepatic enzymes which are involved in combating ROS. Pomegranate peel is rich in phenolic compounds, and different activities of the pomegranate extract can be ascribed to their different phenolic composition.

Pomegranate (Punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. Histopathological studies of the liver of different groups also support the protective effects exhibited by the extract of pomegranate peel by restoring the normal hepatic architecture.

Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure

Michael Aviram, Leslie Dornfeld

Publication : Atherosclerosis http://www.sciencedirect.com/science/article/pii/S0021915001004129

The pomegranate tree, has been extensively used as a folk medicine in many cultures.A study conducted by the authors have identified tannins as the active components responsible for the anti-oxidative properties of pomegranate juice against low-density lipoprotein oxidation. As some antioxidants were recently shown to reduce blood pressure, the authors studied the effect of pomegranate juice consumption by hypertensive patients on their blood pressure and on serum angiotensin converting enzyme (ACE) activity.

A decrement in serum ACE activity and a reduction in systolic blood pressure were noted. Similar dose- dependent inhibitory effect of pomegranate juice on serum ACE activity was observed also in vitro. As reduction in serum ACE activity, even with no decrement in blood pressure,was previously shown to attenuate atherosclerosis, pomegranate juice can offer a wide protectionagainst cardiovascular diseases which could be related to its inhibitory effect on oxidative stress and on serum ACE activity.

The authors conclude that the significant inhibitory effect of pomegranate juice on serum ACE activity and the minor attenuation in blood pressure in hypertensive patients, in addition to its potent inhibitory effect on lipid peroxidation suggests that pomegranate juice consumption can offer a wide protection against cardiovascular diseases.

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.

Michael Aviram;Nina,Volkova ;Dita Presser,Judith Attias;Tony,Hayeka,Mira Rosenblat,Diana Gaitini, Samy Nitecki, Aaron Hoffman, Leslie Dornfeld, Harley Liker.

Publication: Clinical Nutrition http://www.clinicalnutritionjournal.com/article/S0261-5614%2803%2900213-9/pdf

The medicinal properties of pomegranate are described by all major religions and by folk medicine.Earlier studies shows that dietary supplementation with polyphenolic antioxidants to animals was associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. The present study investigates on the effects of pomegranate juice consumption by atherosclerotic patients with carotid artery stenosis on the progression of carotid lesions and changes in oxidative stress and blood pressure. Consumption of pomegranate juice resulted in a significant IMT reduction.

Serum total antioxidant status was increased after one year of pomegranate juice consumption came as complete surprise. Systolic blood pressure was reduced after one year of pomegranate juice consumptio. Serum lipid peroxidation was further reduced after three years of pomegranate juice consumption. The results of the present study thus suggest that these effects could be related to the potent antioxidant characteristics of pomegranate juice polyphenols.

FAQ

1. What are the mechanisms by which pomegranate work in maintaining cardiovascular health?

A wide range of polyphenols (plant chemicals) including tannins, flavonoids and anthocyanins have been found to be present in pomegranate. The hydrolyzable tannins (which include ellagi tannins and gallo tannins) in pomegranate account for 92% of its antioxidant activity. These are the key potent anti-oxidants that give pomegranate its therapeutic value.

Cardio Protect contains pure and powerful pomegranate extract with antioxidant properties that help in reversing arterial wall thickening, and in supporting healthy blood flow. Studies have shown that with its strong antioxidant properties, pomegranate reduces blood pressure and delays the development of atherosclerosis.

2. Can I take Cardio Protect as an adjunct therapy along with other medication for heart health?

Being wholly botanical in nature, Cardio Protect is safe to take as an adjunct with other medication you may be having for heart problems.

3. Why are Curegarden products priced higher than some other botanical products?

Many botanical products available in the market are comprised of whole powdered herbs. Curegarden products are high-end extracts of the active compounds of botanicals, so there is a qualitative difference in the products. For example, you would have to take up to a huge number, for example, 500 capsules of plain turmeric, to equal just one Curegarden BCM-95™ capsule.

Customer Review

"Being a nutritionist to leading sportspersons and filmstars, I am responsible for discovering and recommending the best products on the planet for my clients. So I have to be extra cautious on my recommendations. At Curegarden, I am impressed by the patent pedigree on products, the research gone into them and the personal success I have had using their Tumeric extract products on myself as well as my DAD. At our QUA NUTRITION Clinics our dieticians are using nutraceuticals like gluco balance and daily defense along with the diet plans to impact our customers lives towards healthier living".

Expert Speak By Ryan Fernando

India’s leading sports nutritionist & founder of Qua Nutrition Clinics

CUSTOMER SPEAK

customer
Suma Jayaram

“ I am nearing 50 and now I get small, persistent troubles like pain I my joints, headaches, which were not there before. But with Daily Defense, I have really seen a marked improvement I my general health.Looks like BCM 95 is taking care of my everyday health issues and I am free to enjoy a healthy life."


customer
Rahim K.P.

“I was diagnosed with diabetes in 2005. I had a history of pain in the back and legs, and fatigue.Though I immediately began medication, my blood sugar levels did not respond adequately. I changed my medication, but my blood sugar levels were still fluctuating. I began to look for a natural treatment for diabetes”


customer
Leela Banavara

“I have had tremendous pain and stiffness in my knees for years and have tried several drugs, herbal powders and massages with no relief.After 3 months of taking Joint Rescue, I have significantly increased mobility less stiffness and fatigue”




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 Cardio Protect Capsules | Supplements | Pomegranate Extract
 Cardio Protect Capsules | Supplements | Pomegranate Extract
Natural  Cardio Protect Capsules | Supplements Promoting The Antioxidant Health Of The Heart
Natural  Cardio Protect Capsules | Supplements Promoting The Antioxidant Health Of The Heart & Helps Fight Cell Damaging Free Radicals & Best Supplement For Bp
CARDIO PROTECT
CARDIO PROTECT
Cardio Protect contains our pure and powerful pomegranate extract with antioxidant properties that help in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure. Clinical studies show that pomegranate’s ellagi tannins promote the antioxidant health of the heart and help fight cell damaging free radicals.

Benefits

  • Promotes the antioxidant health of the heart and helps fight cell damaging free radicals
  • Slows down the progression of arterial plaque built up and, in certain cases, may even reverse it
  • Helps in reducing blood pressure by reducing stress-induced vasoconstriction (narrowing) of the blood vessels
  • Prevents the oxidative destruction of nitric oxide, ensuring its availability for its essential vessel-protective functions

Rs. 690.00

60 vegetarian capsules.

Including all taxes and shipping

Avail discount on bulk purchase
5 Units 5% | 10 Units 10%

FREE delivery on orders over Rs. 500/-

COD available | Secure payment

Backed by extensive scientific research and clinical trials Read More>>

Curegarden Natural Cardio Protect: The extraordinary natural protector of heart health

Cardio Protect is a pure and extremely powerful antioxidant that naturally improves cardiovascular health and helps preserve cardiovascular well-being even in healthy people. It naturally protects the health of the heart by assisting in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure.

While pomegranate as a fruit has multiple health benefits, the real source of antioxidants are the hydrolysable tannins, especially the ellagi tannins. The ellagi tannins are not only water soluble but also the major contributors of antioxidant properties that give the fruit its health benefits. What makes Cardio Protect exceptional is the fact that it is composed of Curegarden’s unique pomegranate extract which has been standardized to contain the 100% absorbable ellagi tannins. As a result, the product has a high ORAC (oxygen radical absorbance capacity) value, which is a measure of the antioxidant capacity of a sample.

Cardio Protect is an adjunct therapy. Please consult your physician before use.

Pomegranate – the superfruit with significant cardiovascular benefits!

Pomegranate (Punica granatum) has garnered universal acclaim for its powerful antioxidant properties that make it so beneficial for cardiovascular health. It is one of the tastiest ways to make the heart healthy. In fact, studies have found pomegranate juice to have a higher antioxidant potential than even that of green tea or red wine. A wide range of polyphenols (plant chemicals) including tannins, flavonoids and anthocyanins have been found to be present in pomegranate. The hydrolyzable tannins (which include ellagi tannins and gallo tannins) in pomegranate account for 92% of its antioxidant activity. Ellagi tannins are polyphenols that are unique to pomegranate and are 100% water soluble. These are the key potent anti-oxidants that give pomegranate its therapeutic value.

Studies have shown that due to its strong antioxidant powers, pomegranate has the ability to slow down the build-up of arterial plaques, which leads to atherosclerosis. It also been shown to regulate blood pressure and thereby help in bringing about an overall improvement in the well being of the heart.

Applying Pomegranate’s benefits for the well being of the heart

One of the key underlying causes for atherosclerosis is endothelial dysfunction. The cells that line the blood vessels form the endothelieum. When they develop a defect, it results in impairing blood flow and also causes the accumulation of arterial plaque. Nitric oxide is one of the plays an essential role in protecting the endothelium. It is an important cellular signaling molecule and is involved in many physiological and pathological processes including vasodilation.

Studies have shown that with its strong antioxidant properties, pomegranate exerts its cardiovascular benefits by supporting nitric oxide activity. It protects nitric oxide from oxidative destruction thereby reversing the accumulation of atherogenic plaque.

The antioxidants in pomegranate play a key role in protecting the lipid peroxidation of LDL cholesterol, reducing carotid artery thickness, and lowering the pro-atherogenic effect on arterial walls. It has thus also been proved beneficial in reducing stress-induced vasoconstriction of the blood vessels, in addition to regulating blood pressure.

This formulation is a pure bioavailable form of pomegranate, which is a powerful antioxidant that improves cardiovascular health and preserves cardiovascular wellbeing even in healthy people. . It naturally protects the health of the heart by assisting in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure.

While pomegranate as a fruit has multiple health benefits, the real source of antioxidants are the hydrolysable tannins, especially the ellagi tannins. The ellagi tannins are not only water soluble but also the major contributors of antioxidant properties that give the fruit its health benefits. What makes Cardio Protect exceptional is the fact that it is composed of Curegarden’s unique pomegranate extract which has been standardized to contain the 100% absorbable ellagi tannins. As a result, the product has a high ORAC (oxygen radical absorbance capacity) value, which is a measure of the antioxidant capacity of a sample. Cardio Protect is an adjunct therapy. Please consult your physician before use.

Serving size:

400mg capsules containing:

Carbohydrate: 11.2mg; Protein: 10mg; Fat: 3.6mg; Energy value: 0.12 Kcal/capsule.

Ingredients:

Each 400mg capsule contains pomegranate extract :400 mg 

Recommended usage:

One capsule in the morning and one at night, after food. 

Net content:

60 vegetarian capsules. 

Directions:

Store in a cool and dry place. If pregnant or under medication, consult your health care practitioner before using. Keep out of reach of children.

Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.

Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram

Punblication : Clin Cancer Res 2006;12(13) July 1, 2006 http://clincancerres.aacrjournals.org/content/12/13/4018.full.pdf+html or http://clincancerres.aacrjournals.org/content/12/13/4018.long

The authors' primary intention was to determine the effects of pomegranate juice consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy. The study went on well without any serious adverse events reported and the treatment was well tolerated. Mean PSA doubling time significantly increased with treatment.

Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland

Navindra P. Seeram William J. Aronson , Yanjun Zhang , Susanne M. Henning , Aune Moro, Ru-po Lee, Maryam Sartippour , Diane M. Harris , Matthew Rettig , Marc A. Suchard ,Allan J. Pantuck , Arie Belldegrun and David Heber .

Publication : J. Agric. Food Chem. 2007, 55, 7732–7737 http://pubs.acs.org/doi/pdfplus/10.1021/jf071303g

Present study suggest the potential for pomegranate products to play a role in prostate cancer chemoprevention . Ellagic acid and several synthesized urolithins were shown to inhibit the growth of human prostate cancer cells in vitro

Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB- dependent mechanism.

Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A.

Publication : Mol Cancer Ther. 2008 Sep; 7(9): 2662–2671. http://mct.aacrjournals.org/content/7/9/2662.full.pdf+html

Dietary agents such as pomegranate extract (PE) have received increasing attention as potential agents to prevent the onset or progression of many malignancies, including prostate cancer. Dietary agents with preventive potential can be applied at various points in the natural and treated history of prostate cancer. For example, in addition to primary prevention, pomegranate consumption could potentially be used to prevent or delay clinical recurrences once patients experience biochemical recurrences after radical prostatectomy

Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.

Arshi Malik, Farrukh Afaq, Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, and Hasan Mukhtar

Publication: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8. Epub 2005 Sep 28 http://www.pnas.org/content/102/41/14813.full.pdf

The present findings suggest that the fruit pomegranate and its associated antioxidants may possess a strong potential for development as a chemo preventive and possibly therapeutic agent against prostate cancer. Prostate cancer is the most common invasive malignancy and the second leading cause of cancer- related deaths among U.S. males,with a similar trend in many other countries. One approach to control this malignancy is its prevention through the use of agents present in diet consumed by humans. Pomegranate possesses strong antioxidant and anti-inflammatory properties.

The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

Kroeger N, Belldegrun AS, Pantuck AJ.

Publication: Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013), http://www.hindawi.com/journals/ecam/2013/701434/

The authors reports that the most striking evidence for the biological activity of pomegranate extracts is in controlling prostate cancer cells. In vivo and in vitro studies have shown that pomegranate extracts are capable of inhibiting tumor cell proliferation, migration, and invasion, while also inducing apoptosis.

Studies on Antioxidant Activity of Pomegranate (Punica granatum) Peel Extract Using in Vivo Models.

Kotamballi N. Chidambara Murthy,Guddadarangavvahally.K. Jayaprakasha,Ravendra P. Singh

Publication J. Agric. Food Chem. https://goo.gl/Ctlmwl

The results of the present work reiterate that the pomegranate peel extract is capable of enhancing or maintaining the activity of hepatic enzymes which are involved in combating ROS. Pomegranate peel is rich in phenolic compounds, and different activities of the pomegranate extract can be ascribed to their different phenolic composition.

Pomegranate (Punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. Histopathological studies of the liver of different groups also support the protective effects exhibited by the extract of pomegranate peel by restoring the normal hepatic architecture.

Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure

Michael Aviram, Leslie Dornfeld

Publication : Atherosclerosis http://www.sciencedirect.com/science/article/pii/S0021915001004129

The pomegranate tree, has been extensively used as a folk medicine in many cultures.A study conducted by the authors have identified tannins as the active components responsible for the anti-oxidative properties of pomegranate juice against low-density lipoprotein oxidation. As some antioxidants were recently shown to reduce blood pressure, the authors studied the effect of pomegranate juice consumption by hypertensive patients on their blood pressure and on serum angiotensin converting enzyme (ACE) activity.

A decrement in serum ACE activity and a reduction in systolic blood pressure were noted. Similar dose- dependent inhibitory effect of pomegranate juice on serum ACE activity was observed also in vitro. As reduction in serum ACE activity, even with no decrement in blood pressure,was previously shown to attenuate atherosclerosis, pomegranate juice can offer a wide protectionagainst cardiovascular diseases which could be related to its inhibitory effect on oxidative stress and on serum ACE activity.

The authors conclude that the significant inhibitory effect of pomegranate juice on serum ACE activity and the minor attenuation in blood pressure in hypertensive patients, in addition to its potent inhibitory effect on lipid peroxidation suggests that pomegranate juice consumption can offer a wide protection against cardiovascular diseases.

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.

Michael Aviram;Nina,Volkova ;Dita Presser,Judith Attias;Tony,Hayeka,Mira Rosenblat,Diana Gaitini, Samy Nitecki, Aaron Hoffman, Leslie Dornfeld, Harley Liker.

Publication: Clinical Nutrition http://www.clinicalnutritionjournal.com/article/S0261-5614%2803%2900213-9/pdf

The medicinal properties of pomegranate are described by all major religions and by folk medicine.Earlier studies shows that dietary supplementation with polyphenolic antioxidants to animals was associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. The present study investigates on the effects of pomegranate juice consumption by atherosclerotic patients with carotid artery stenosis on the progression of carotid lesions and changes in oxidative stress and blood pressure. Consumption of pomegranate juice resulted in a significant IMT reduction.

Serum total antioxidant status was increased after one year of pomegranate juice consumption came as complete surprise. Systolic blood pressure was reduced after one year of pomegranate juice consumptio. Serum lipid peroxidation was further reduced after three years of pomegranate juice consumption. The results of the present study thus suggest that these effects could be related to the potent antioxidant characteristics of pomegranate juice polyphenols.

1. What are the mechanisms by which pomegranate work in maintaining cardiovascular health?

A wide range of polyphenols (plant chemicals) including tannins, flavonoids and anthocyanins have been found to be present in pomegranate. The hydrolyzable tannins (which include ellagi tannins and gallo tannins) in pomegranate account for 92% of its antioxidant activity. These are the key potent anti-oxidants that give pomegranate its therapeutic value.

Cardio Protect contains pure and powerful pomegranate extract with antioxidant properties that help in reversing arterial wall thickening, and in supporting healthy blood flow. Studies have shown that with its strong antioxidant properties, pomegranate reduces blood pressure and delays the development of atherosclerosis.

2. Can I take Cardio Protect as an adjunct therapy along with other medication for heart health?

Being wholly botanical in nature, Cardio Protect is safe to take as an adjunct with other medication you may be having for heart problems.

3. Why are Curegarden products priced higher than some other botanical products?

Many botanical products available in the market are comprised of whole powdered herbs. Curegarden products are high-end extracts of the active compounds of botanicals, so there is a qualitative difference in the products. For example, you would have to take up to a huge number, for example, 500 capsules of plain turmeric, to equal just one Curegarden BCM-95™ capsule.

  • PRODUCT DETAILS

    Curegarden Natural Cardio Protect: The extraordinary natural protector of heart health

    Cardio Protect is a pure and extremely powerful antioxidant that naturally improves cardiovascular health and helps preserve cardiovascular well-being even in healthy people. It naturally protects the health of the heart by assisting in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure.

    While pomegranate as a fruit has multiple health benefits, the real source of antioxidants are the hydrolysable tannins, especially the ellagi tannins. The ellagi tannins are not only water soluble but also the major contributors of antioxidant properties that give the fruit its health benefits. What makes Cardio Protect exceptional is the fact that it is composed of Curegarden’s unique pomegranate extract which has been standardized to contain the 100% absorbable ellagi tannins. As a result, the product has a high ORAC (oxygen radical absorbance capacity) value, which is a measure of the antioxidant capacity of a sample.

    Cardio Protect is an adjunct therapy. Please consult your physician before use.

    Pomegranate – the superfruit with significant cardiovascular benefits!

    Pomegranate (Punica granatum) has garnered universal acclaim for its powerful antioxidant properties that make it so beneficial for cardiovascular health. It is one of the tastiest ways to make the heart healthy. In fact, studies have found pomegranate juice to have a higher antioxidant potential than even that of green tea or red wine. A wide range of polyphenols (plant chemicals) including tannins, flavonoids and anthocyanins have been found to be present in pomegranate. The hydrolyzable tannins (which include ellagi tannins and gallo tannins) in pomegranate account for 92% of its antioxidant activity. Ellagi tannins are polyphenols that are unique to pomegranate and are 100% water soluble. These are the key potent anti-oxidants that give pomegranate its therapeutic value.

    Studies have shown that due to its strong antioxidant powers, pomegranate has the ability to slow down the build-up of arterial plaques, which leads to atherosclerosis. It also been shown to regulate blood pressure and thereby help in bringing about an overall improvement in the well being of the heart.

    Applying Pomegranate’s benefits for the well being of the heart

    One of the key underlying causes for atherosclerosis is endothelial dysfunction. The cells that line the blood vessels form the endothelieum. When they develop a defect, it results in impairing blood flow and also causes the accumulation of arterial plaque. Nitric oxide is one of the plays an essential role in protecting the endothelium. It is an important cellular signaling molecule and is involved in many physiological and pathological processes including vasodilation.

    Studies have shown that with its strong antioxidant properties, pomegranate exerts its cardiovascular benefits by supporting nitric oxide activity. It protects nitric oxide from oxidative destruction thereby reversing the accumulation of atherogenic plaque.

    The antioxidants in pomegranate play a key role in protecting the lipid peroxidation of LDL cholesterol, reducing carotid artery thickness, and lowering the pro-atherogenic effect on arterial walls. It has thus also been proved beneficial in reducing stress-induced vasoconstriction of the blood vessels, in addition to regulating blood pressure.

  • HOW IT WORKS
    This formulation is a pure bioavailable form of pomegranate, which is a powerful antioxidant that improves cardiovascular health and preserves cardiovascular wellbeing even in healthy people. . It naturally protects the health of the heart by assisting in reversing arterial wall thickening, supporting healthy blood flow, and maintaining normal blood pressure.

    While pomegranate as a fruit has multiple health benefits, the real source of antioxidants are the hydrolysable tannins, especially the ellagi tannins. The ellagi tannins are not only water soluble but also the major contributors of antioxidant properties that give the fruit its health benefits. What makes Cardio Protect exceptional is the fact that it is composed of Curegarden’s unique pomegranate extract which has been standardized to contain the 100% absorbable ellagi tannins. As a result, the product has a high ORAC (oxygen radical absorbance capacity) value, which is a measure of the antioxidant capacity of a sample. Cardio Protect is an adjunct therapy. Please consult your physician before use.
  • FACT SHEET

    Serving size:

    400mg capsules containing:

    Carbohydrate: 11.2mg; Protein: 10mg; Fat: 3.6mg; Energy value: 0.12 Kcal/capsule.

    Ingredients:

    Each 400mg capsule contains pomegranate extract :400 mg 

    Recommended usage:

    One capsule in the morning and one at night, after food. 

    Net content:

    60 vegetarian capsules. 

    Directions:

    Store in a cool and dry place. If pregnant or under medication, consult your health care practitioner before using. Keep out of reach of children.
  • SCIENTIFIC PAPERS

    Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.

    Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram

    Punblication : Clin Cancer Res 2006;12(13) July 1, 2006 http://clincancerres.aacrjournals.org/content/12/13/4018.full.pdf+html or http://clincancerres.aacrjournals.org/content/12/13/4018.long

    The authors' primary intention was to determine the effects of pomegranate juice consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy. The study went on well without any serious adverse events reported and the treatment was well tolerated. Mean PSA doubling time significantly increased with treatment.

    Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland

    Navindra P. Seeram William J. Aronson , Yanjun Zhang , Susanne M. Henning , Aune Moro, Ru-po Lee, Maryam Sartippour , Diane M. Harris , Matthew Rettig , Marc A. Suchard ,Allan J. Pantuck , Arie Belldegrun and David Heber .

    Publication : J. Agric. Food Chem. 2007, 55, 7732–7737 http://pubs.acs.org/doi/pdfplus/10.1021/jf071303g

    Present study suggest the potential for pomegranate products to play a role in prostate cancer chemoprevention . Ellagic acid and several synthesized urolithins were shown to inhibit the growth of human prostate cancer cells in vitro

    Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB- dependent mechanism.

    Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A.

    Publication : Mol Cancer Ther. 2008 Sep; 7(9): 2662–2671. http://mct.aacrjournals.org/content/7/9/2662.full.pdf+html

    Dietary agents such as pomegranate extract (PE) have received increasing attention as potential agents to prevent the onset or progression of many malignancies, including prostate cancer. Dietary agents with preventive potential can be applied at various points in the natural and treated history of prostate cancer. For example, in addition to primary prevention, pomegranate consumption could potentially be used to prevent or delay clinical recurrences once patients experience biochemical recurrences after radical prostatectomy

    Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.

    Arshi Malik, Farrukh Afaq, Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, and Hasan Mukhtar

    Publication: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8. Epub 2005 Sep 28 http://www.pnas.org/content/102/41/14813.full.pdf

    The present findings suggest that the fruit pomegranate and its associated antioxidants may possess a strong potential for development as a chemo preventive and possibly therapeutic agent against prostate cancer. Prostate cancer is the most common invasive malignancy and the second leading cause of cancer- related deaths among U.S. males,with a similar trend in many other countries. One approach to control this malignancy is its prevention through the use of agents present in diet consumed by humans. Pomegranate possesses strong antioxidant and anti-inflammatory properties.

    The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

    The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

    Kroeger N, Belldegrun AS, Pantuck AJ.

    Publication: Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013), http://www.hindawi.com/journals/ecam/2013/701434/

    The authors reports that the most striking evidence for the biological activity of pomegranate extracts is in controlling prostate cancer cells. In vivo and in vitro studies have shown that pomegranate extracts are capable of inhibiting tumor cell proliferation, migration, and invasion, while also inducing apoptosis.

    Studies on Antioxidant Activity of Pomegranate (Punica granatum) Peel Extract Using in Vivo Models.

    Kotamballi N. Chidambara Murthy,Guddadarangavvahally.K. Jayaprakasha,Ravendra P. Singh

    Publication J. Agric. Food Chem. https://goo.gl/Ctlmwl

    The results of the present work reiterate that the pomegranate peel extract is capable of enhancing or maintaining the activity of hepatic enzymes which are involved in combating ROS. Pomegranate peel is rich in phenolic compounds, and different activities of the pomegranate extract can be ascribed to their different phenolic composition.

    Pomegranate (Punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. Histopathological studies of the liver of different groups also support the protective effects exhibited by the extract of pomegranate peel by restoring the normal hepatic architecture.

    Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure

    Michael Aviram, Leslie Dornfeld

    Publication : Atherosclerosis http://www.sciencedirect.com/science/article/pii/S0021915001004129

    The pomegranate tree, has been extensively used as a folk medicine in many cultures.A study conducted by the authors have identified tannins as the active components responsible for the anti-oxidative properties of pomegranate juice against low-density lipoprotein oxidation. As some antioxidants were recently shown to reduce blood pressure, the authors studied the effect of pomegranate juice consumption by hypertensive patients on their blood pressure and on serum angiotensin converting enzyme (ACE) activity.

    A decrement in serum ACE activity and a reduction in systolic blood pressure were noted. Similar dose- dependent inhibitory effect of pomegranate juice on serum ACE activity was observed also in vitro. As reduction in serum ACE activity, even with no decrement in blood pressure,was previously shown to attenuate atherosclerosis, pomegranate juice can offer a wide protectionagainst cardiovascular diseases which could be related to its inhibitory effect on oxidative stress and on serum ACE activity.

    The authors conclude that the significant inhibitory effect of pomegranate juice on serum ACE activity and the minor attenuation in blood pressure in hypertensive patients, in addition to its potent inhibitory effect on lipid peroxidation suggests that pomegranate juice consumption can offer a wide protection against cardiovascular diseases.

    Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.

    Michael Aviram;Nina,Volkova ;Dita Presser,Judith Attias;Tony,Hayeka,Mira Rosenblat,Diana Gaitini, Samy Nitecki, Aaron Hoffman, Leslie Dornfeld, Harley Liker.

    Publication: Clinical Nutrition http://www.clinicalnutritionjournal.com/article/S0261-5614%2803%2900213-9/pdf

    The medicinal properties of pomegranate are described by all major religions and by folk medicine.Earlier studies shows that dietary supplementation with polyphenolic antioxidants to animals was associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. The present study investigates on the effects of pomegranate juice consumption by atherosclerotic patients with carotid artery stenosis on the progression of carotid lesions and changes in oxidative stress and blood pressure. Consumption of pomegranate juice resulted in a significant IMT reduction.

    Serum total antioxidant status was increased after one year of pomegranate juice consumption came as complete surprise. Systolic blood pressure was reduced after one year of pomegranate juice consumptio. Serum lipid peroxidation was further reduced after three years of pomegranate juice consumption. The results of the present study thus suggest that these effects could be related to the potent antioxidant characteristics of pomegranate juice polyphenols.

  • FAQ

    1. What are the mechanisms by which pomegranate work in maintaining cardiovascular health?

    A wide range of polyphenols (plant chemicals) including tannins, flavonoids and anthocyanins have been found to be present in pomegranate. The hydrolyzable tannins (which include ellagi tannins and gallo tannins) in pomegranate account for 92% of its antioxidant activity. These are the key potent anti-oxidants that give pomegranate its therapeutic value.

    Cardio Protect contains pure and powerful pomegranate extract with antioxidant properties that help in reversing arterial wall thickening, and in supporting healthy blood flow. Studies have shown that with its strong antioxidant properties, pomegranate reduces blood pressure and delays the development of atherosclerosis.

    2. Can I take Cardio Protect as an adjunct therapy along with other medication for heart health?

    Being wholly botanical in nature, Cardio Protect is safe to take as an adjunct with other medication you may be having for heart problems.

    3. Why are Curegarden products priced higher than some other botanical products?

    Many botanical products available in the market are comprised of whole powdered herbs. Curegarden products are high-end extracts of the active compounds of botanicals, so there is a qualitative difference in the products. For example, you would have to take up to a huge number, for example, 500 capsules of plain turmeric, to equal just one Curegarden BCM-95™ capsule.

By RYAN FERNANDO, Banglore

"Being a nutritionist to leading sportspersons and filmstars, I am responsible for discovering and recommending the best products on the planet for my clients. So I have to be extra cautious on my recommendations. At Curegarden, I am impressed by the patent pedigree on products, the research gone into them and the personal success I have had using their Tumeric extract products on myself as well as my DAD. At our QUA NUTRITION Clinics our dieticians are using nutraceuticals like gluco balance and daily defense along with the diet plans to impact our customers lives towards healthier living."

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ABOUT CUREGARDEN


Curegarden represents a dream. A dream of sharing a happier, healthier body and quality of life with the use of nature's best ingredients. Botanics, when extracted for their bioactive compounds, offer a most effective approach to improving well-being and quality of life. It is based on the belief that botanicals of the highest quality would have a positive effect — without any negative side effects — on people's health. Over the years,we have seen and experienced personally the wonderful benefits of these high quality botanical products and are delighted to share them with others.


ABOUT ARJUNA NATURALS


Arjuna Natural Ltd is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for over two decades. With customers in around 40 countries, the company has close to 50 patents to its credit of which majority are commercialized globally. The company has R&D tie ups with international universities from Australia, US and Japan. The highly advanced R&D unit at Arjuna is a complete research facility for phytochemistry, pharmacokinetics, formulation and development, pre-clinical and clinical studies.


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