Manage respiratory disorders with an effective long-term solution
Breathe Sure is a powerful natural solution for the effective regulation of respiratory disorders and infections. It contains the well-researched botanical Boswelliaserrata, widely studied for its anti-oxidant and anti-inflammatory properties. The exceptional efficacy of Breathe Sure can be attributed to theBoswellia extract that it contains, standardized to the powerful bioactive ingredient AKBA (acetyl ketoboswellic acid).
Studies have proved that AKBA has the unique ability to inhibit both 5LOX (5 lipoxygenase) and HLE (human leukocyte elastase), that are the biomolecules responsible for bronchial muscle contraction and mucous secretion respectively. By this mechanism, Breathe Sure helps relieve breathlessness, tightness of the chest, coughing and wheezing, and is therefore effective in the management of respiratory tract disorders and infections. The dual inhibition of 5-LO and HLE is unique to boswellic acids. AKBA alone is not sufficientto get the full benefits of boswellia: the synergism between AKBA and other acetyl group of BA in boswellia gives it its superior anti- inflammatory activity.
Mechanism of action
The key active ingredient of the boswelliaserrata extract are the boswellic acids (BA). Of the various acids, the acetyl group of BA is the most potent anti- inflammatory agents. and the most active acetyl BA is Acetyl ketoboswellic acid (AKBA). Breathe Sure is standardised with acetyl group of BA with 10% AKBA.
Boswellic acids are specific, non-reducing type inhibitors of 5-lipoxygenase (5-LO), one of the two key enzymes in arachidonic acid metabolism and eicosanoid synthesis leading to inflammation. 5-LO catalyzes the first two steps in the biosynthesis of leukotrienes (LTs) from arachidonic acid to 5-hydroperoxyeicosatetraenoic acid (5(S)-HETE) and subsequently to LTA4, which is further converted to LTB4. LT cause broncho-constriction and mucus secretion and induce plasma exudation, that plays an important role in asthma.
BA also inhibits human leukocyte elastase (HLE) which stimulates mucus secretion and thus may play a role in cystic fibrosis, chronic bronchitis and acute respiratory distress syndrome. HLE initiates injury to the tissues triggering the inflammatory process.