Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial.

Nataša Fidler, Thorsten Sauerwald,Anja Pohl,Hans Demmelmair and Berthold Koletzko1

Publication: Journal of Lipid Research http://www.jlr.org/content/41/9/1376.long

The long-chain polyunsaturated fatty acid , Docosahexaenoic acid (DHA) is an essential structural component in tissue membranes of the human body and is highly concentrated in brain and retina. Inadequate early intake may affect later visual function and neuro development .

Hence Docosahexaenoic acid (DHA) is important for infant development. The authors studied the effects of DHA supplementation on the fatty acid composition of human milk and the secretion of dietary 13C- labeled fatty acids, including DHA, into human milk. Dietary DHA supplementation increases the DHA content in human milk. DHA transfer from the diet into human milk is comparable to palmitic and oleic acid transfer.

This study shows that dietary DHA intake has a specific effect on breast milk DHA content.

Prenatal Docosahexaenoic Acid Supplementation and Infant Morbidity: Randomized Controlled Trial

Beth Imhoff-Kunsch, MPH, PhD, Aryeh D. Stein, MPH, PhD, Reynaldo,Martorell, PhD,Socorro Parra- Cabrera, PhD, Isabelle Romieu, MD, MPH,ScD, and Usha Ramakrishnan, PhD

Publication : Pediatrics http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164093/pdf/zpee505.pdf

The present study reveals the probable effects of prenatal DHA supplementation on infant morbidity. The researchers have concluded that DHA supplementation during pregnancy decreased the occurrence of colds in children at one month and influenced illness symptom duration at one, three, and six months . This in-depth and pains taking research findings contribute to the accumulating evidence base for a relationship of prenatal n-3 PUFA nutrition to the development of fetal and neonatal immune function.

Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico.

Ramakrishnan U, Stein AD, Parra-Cabrera S, Wang M, Imhoff-Kunsch B, Juárez-Márquez S, Rivera J, Martorell R.

Publication : Food Nutr Bull . http://www.ncbi.nlm.nih.gov/pubmed/20715595

http://fnb.sagepub.com/content/31/2_suppl2/S108.full.pdf+html

This informative article based on research conducted in Mexico suggests that prenatal DHA supplementation of primigravid women may result in increased birth size in a population where dietary DHA intakes are very low.

EFFECT OF N-3 POLYUNSATURATED FATTY ACID SUPPLEMENTATION IN PREGNANCY: THE NUHEAL TRIAL

Tamás Decsi, Cristina Campoy, Berthold Koletzko

Publication: Adv Exp Med Biol. http://eknygos.lsmuni.lt/springer/128/109-113.pdf

The authors have carried out an extensive study on the beneficial effects of DHA supplementation in a dose of 400mg/day from the 20th week onwards during pregnancy. They conclude that it further enhances the fatty acid composition of cord blood lipids in addition to the enhancement of maternal and placental blood lipids. Hence the present results indicate that 400 mg/day might be an effective dosage of DHA supplementation during pregnancy.