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Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults.

A. Veronica Witte, Lucia Kerti, Henrike M. Herm annstädter,Jochen B. Fiebach1,, Stephan J. Schreiber, Jan Philipp Schuchardt,Andreas Hahn and Agnes Flöel

Publication: Cerebral Cortex http://cercor.oxfordjournals.org/content/early/2013/06/23/cercor.bht163.full.pdf+html

A detailed research report by the authors suggests that higher intake of seafish or oil rich in long-chain omega-3 polyunsaturated fatty acids may be beneficial for the aging brain.

This interventional study demonstrates enhanced executive functions in healthy older adults after 26 weeks of high levels of supplementary marine long chain -omega 3- fatty acids compared with placebo. which is in line with previous studies reporting beneficial effects of long chain -omega3 - fatty acids on cognition.The study shows positive effects of long chain -omega3 - fatty acids on neuronal function.

These findings may help to develop new prevention and treatment strategies for maintaining cognitive health into older age.


Tejaswi Chavan, Suresh Khadke, Shubhangi Harke, Abhijit Ghadge, Manjiri Karandikar, Vijaya Pandit, Prabhakar Ranjekar, Omkar Kulkarni and Aniket Kuvalekar

Publication: International Journal of Pharma and Bio Sciences http://www.ijpbs.net/download.php?download_file=cms/php/upload/2129_pdf.pdf&did=2129

The present study aims to understand the hepato protective potential of omega-3 fatty acids in the form of flaxseed oil and fish oil. The study concludes that flaxseed oil or fish oil prevents hepatic damage with marked improvement in hepatic function and normalization of lipid profiles in serum and liver. The protective effects of fish oil and flaxseed oil are mainly attributed to long chain polyunsaturated fatty acids like ALA, EPA and DHA. These fatty acids have been shown to have antioxidant properties and play an important role in overall metabolism.

EPA and DHA increased PPARγ expression and deceased integrinlinked kinase and integrin β1 expression in rat glomerular mesangial cells treated with lipopolysaccharide

Wenchao Han, Hui Zhao, Bo Jiao, Fange Liu

Publication: BioScience Trends. 2014; 8(2):120-125. http://www.biosciencetrends.com/files/BST_2014Vol8No2_pp68_137.pdf

Fish oil containing ω-3 polyunsaturated fatty acids (ω-3 PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is known to prevent the progression of nephropathy and retard the progression of kidney disease. This study provides extremely novel insights into the mechanisms of the renoprotective effects of fish oil.

Effects of ω -3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial

Natalie Sinn, Catherine M. Milte, Steven J. Street, Jonathan D. Buckley, Alison M. Coates,John Petkov and Peter R. C. Howe

Publication: British Journal of Nutrition http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN107_11%2FS0007114511004788a.pdf &code=5cece60777254096b810d4d41529542f

The present study carefully investigates the benefits of supplementing a diet with ω-3 PUFA, DHA and EPA, for depressive symptoms, quality of life (QOL) and cognition in elderly people with MCI.

In conclusion, these results indicate that DHA-rich and EPA-rich fish oils may be effective for depressive symptoms and health parameters, exerting variable effects on cognitive and physical outcomes.

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells1,2,3

Mark Bouwens, Ondine van de Rest, Neele Dellschaft,Mechteld Grootte Bromhaar, Lisette CPGM de Groot,Johanna M Geleijnse, Michael Müller, and Lydia A Afman

Publication: The American Journal of Clinical Nutrition http://ajcn.nutrition.org/content/90/2/415.abstract

Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs).This pioneering research shows that intake of EPA+DHA for 26 weeks can alter the gene expression profiles of PBMCs to a more anti-inflammatory and antiatherogenic status.

Beneficial effects of flaxseed oil and fish oil diet are through modulation of different hepatic genes involved in lipid metabolism in streptozotocin–nicotinamide induced diabetic rats

Prasad P. Devarshi , Nivedita M. Jangale ,Arvindkumar E. Ghule , Subhash L. Bodhankar ,Abhay M. Harsulkar

Publication: Genes Nutr. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639321/pdf/12263_2012_Article_326.pdf

Dietary omega-3 fatty acids have been demonstrated to have positive physiological effects on lipid metabolism, cardiovascular system and insulin resistance.Type-2 diabetes (T2DM) is known for perturbations in fatty acid metabolism leading to dyslipidemia.

The authors say " Dietary flaxseed oil and fish oil have therapeutic potential in preventing lipid abnormalities in T2DM.”

The Effect of Dietary ω-3 Fatty Acids on Coronary Atherosclerosis A Randomized, Double-Blind, Placebo Controlled Trial.

Clemens von Schacky, MD; Peter Angerer, MD; Wolfgang Kothny, MD; Karl Theisen, MD and Harald Mudra, MD

Publication: Annals of Internal Medicine. http://www.ncbi.nlm.nih.gov/pubmed/10189324


This research was to study the effect of dietary intake of ω-3 fatty acids on the course of coronary artery atherosclerosis in humans.

The authors precisely observe that patients with coronary artery disease who ingested approximately 1.5 g of ω-3 fatty acids per day for 2 years had less progression and more regression of coronary artery disease on coronary angiography than did comparable patients who ingested a placebo..”

Scientific Opinion on the Tolerable Upper Intake Level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid

EFSA Panel on Dietetic Products

Publication: EFSA Journal http://www.efsa.europa.eu/en/efsajournal/pub/2815

Optimum level of EPA and DHA intakes are studied by the panel and reported . The Panel considers that supplemental intakes of DHA alone up to about one gram per day do not raise safety concerns for the general population .



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Arjuna Natural Extracts Ltd is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for over two decades. With customers in around 40 countries, the company has close to 50 patents to its credit of which majority are commercialized globally. The company has R&D tie ups with international universities from Australia, US and Japan. The highly advanced R&D unit at Arjuna is a complete research facility for phytochemistry, pharmacokinetics, formulation and development, pre-clinical and clinical studies.