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Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.

Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram

Punblication : Clin Cancer Res 2006;12(13) July 1, 2006 http://clincancerres.aacrjournals.org/content/12/13/4018.full.pdf+html or http://clincancerres.aacrjournals.org/content/12/13/4018.long

The authors' primary intention was to determine the effects of pomegranate juice consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy. The study went on well without any serious adverse events reported and the treatment was well tolerated. Mean PSA doubling time significantly increased with treatment.

Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland

Navindra P. Seeram William J. Aronson , Yanjun Zhang , Susanne M. Henning , Aune Moro, Ru-po Lee, Maryam Sartippour , Diane M. Harris , Matthew Rettig , Marc A. Suchard ,Allan J. Pantuck , Arie Belldegrun and David Heber .

Publication : J. Agric. Food Chem. 2007, 55, 7732–7737 http://pubs.acs.org/doi/pdfplus/10.1021/jf071303g

Present study suggest the potential for pomegranate products to play a role in prostate cancer chemoprevention . Ellagic acid and several synthesized urolithins were shown to inhibit the growth of human prostate cancer cells in vitro

Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB- dependent mechanism.

Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A.

Publication : Mol Cancer Ther. 2008 Sep; 7(9): 2662–2671. http://mct.aacrjournals.org/content/7/9/2662.full.pdf+html

Dietary agents such as pomegranate extract (PE) have received increasing attention as potential agents to prevent the onset or progression of many malignancies, including prostate cancer. Dietary agents with preventive potential can be applied at various points in the natural and treated history of prostate cancer. For example, in addition to primary prevention, pomegranate consumption could potentially be used to prevent or delay clinical recurrences once patients experience biochemical recurrences after radical prostatectomy

Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.

Arshi Malik, Farrukh Afaq, Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, and Hasan Mukhtar

Publication: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8. Epub 2005 Sep 28 http://www.pnas.org/content/102/41/14813.full.pdf

The present findings suggest that the fruit pomegranate and its associated antioxidants may possess a strong potential for development as a chemo preventive and possibly therapeutic agent against prostate cancer. Prostate cancer is the most common invasive malignancy and the second leading cause of cancer- related deaths among U.S. males,with a similar trend in many other countries. One approach to control this malignancy is its prevention through the use of agents present in diet consumed by humans. Pomegranate possesses strong antioxidant and anti-inflammatory properties.

The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

The present study is the first report showing the effect of the fruit pomegranate in inhibiting human prostate carcinoma cell growth in an in vitro and in vivo preclinical model. The reduction in tumor growth with concomitant reduction in PSA levels observed in the xenograft model may have human clinical relevance. The outcome of this study could have a direct practical implication and translational relevance to prostate cancer patients, because it suggests that pomegranate consumption may retard prostate cancer progression, and improve the quality of life of the patients.

Kroeger N, Belldegrun AS, Pantuck AJ.

Publication: Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013), http://www.hindawi.com/journals/ecam/2013/701434/

The authors reports that the most striking evidence for the biological activity of pomegranate extracts is in controlling prostate cancer cells. In vivo and in vitro studies have shown that pomegranate extracts are capable of inhibiting tumor cell proliferation, migration, and invasion, while also inducing apoptosis.

Studies on Antioxidant Activity of Pomegranate (Punica granatum) Peel Extract Using in Vivo Models.

Kotamballi N. Chidambara Murthy,Guddadarangavvahally.K. Jayaprakasha,Ravendra P. Singh

Publication J. Agric. Food Chem. https://goo.gl/Ctlmwl

The results of the present work reiterate that the pomegranate peel extract is capable of enhancing or maintaining the activity of hepatic enzymes which are involved in combating ROS. Pomegranate peel is rich in phenolic compounds, and different activities of the pomegranate extract can be ascribed to their different phenolic composition.

Pomegranate (Punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. Histopathological studies of the liver of different groups also support the protective effects exhibited by the extract of pomegranate peel by restoring the normal hepatic architecture.

Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure

Michael Aviram, Leslie Dornfeld

Publication : Atherosclerosis http://www.sciencedirect.com/science/article/pii/S0021915001004129

The pomegranate tree, has been extensively used as a folk medicine in many cultures.A study conducted by the authors have identified tannins as the active components responsible for the anti-oxidative properties of pomegranate juice against low-density lipoprotein oxidation. As some antioxidants were recently shown to reduce blood pressure, the authors studied the effect of pomegranate juice consumption by hypertensive patients on their blood pressure and on serum angiotensin converting enzyme (ACE) activity.

A decrement in serum ACE activity and a reduction in systolic blood pressure were noted. Similar dose- dependent inhibitory effect of pomegranate juice on serum ACE activity was observed also in vitro. As reduction in serum ACE activity, even with no decrement in blood pressure,was previously shown to attenuate atherosclerosis, pomegranate juice can offer a wide protectionagainst cardiovascular diseases which could be related to its inhibitory effect on oxidative stress and on serum ACE activity.

The authors conclude that the significant inhibitory effect of pomegranate juice on serum ACE activity and the minor attenuation in blood pressure in hypertensive patients, in addition to its potent inhibitory effect on lipid peroxidation suggests that pomegranate juice consumption can offer a wide protection against cardiovascular diseases.

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.

Michael Aviram;Nina,Volkova ;Dita Presser,Judith Attias;Tony,Hayeka,Mira Rosenblat,Diana Gaitini, Samy Nitecki, Aaron Hoffman, Leslie Dornfeld, Harley Liker.

Publication: Clinical Nutrition http://www.clinicalnutritionjournal.com/article/S0261-5614%2803%2900213-9/pdf

The medicinal properties of pomegranate are described by all major religions and by folk medicine.Earlier studies shows that dietary supplementation with polyphenolic antioxidants to animals was associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. The present study investigates on the effects of pomegranate juice consumption by atherosclerotic patients with carotid artery stenosis on the progression of carotid lesions and changes in oxidative stress and blood pressure. Consumption of pomegranate juice resulted in a significant IMT reduction.

Serum total antioxidant status was increased after one year of pomegranate juice consumption came as complete surprise. Systolic blood pressure was reduced after one year of pomegranate juice consumptio. Serum lipid peroxidation was further reduced after three years of pomegranate juice consumption. The results of the present study thus suggest that these effects could be related to the potent antioxidant characteristics of pomegranate juice polyphenols.

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ABOUT ARJUNA NATURALS


Arjuna Natural Extracts Ltd is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for over two decades. With customers in around 40 countries, the company has close to 50 patents to its credit of which majority are commercialized globally. The company has R&D tie ups with international universities from Australia, US and Japan. The highly advanced R&D unit at Arjuna is a complete research facility for phytochemistry, pharmacokinetics, formulation and development, pre-clinical and clinical studies.


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