More than many other age-linked diseases, cancer results from the accumulative effect of years of small-scale offenses on the body. Inflammation, oxidation, stress, infection, and other physiological assaults exact their dues, wreaking dangerous damage over time that sets abnormal cell proliferation in motion. There is an urgent need to provide ageing bodies with authenticated interventions to target cancer’s multiple causative factors — sometimes even before they take hold.
Among the most persuasive and under-renowned of these validated therapies is curcumin. Curcumin has emerged as a potent multimodal cancer-preventing agent, with 870 published studies appearing in scientific literature globally in the past year alone!
The latest research demonstrates curcumin’s power to disrupt specific molecular mechanisms that lead to cancer — and, to treat the disease in many cases, and found to be particularly effective in certain kinds of cancers in women, prostate cancer, and gastrointestinal cancer.
Curcumin intervenes at each stage in the complex sequence of events that must occur in order for a cancer to develop, progress, invade, and ultimately metastasize to healthy tissue.
System-wide, safe, multimodal defense
The anti-inflammatory and antioxidant powers of curcumin are the foundation of its ability to prevent and treat cancer, since cancer is caused by inflammation and oxidative stress, meaning, among other things, that DNA has been damaged, impairing the ability of cells to reproduce perfectly.
The staid and highly respected MD Anderson Cancer Centre has expressed uncharacteristic enthusiasm about curcumin’s anti-cancer properties. In a 2003 statement by researchers published in the Journal Anti-cancer Research: “Extensive research over the last 50 years has indicated it can prevent and treat cancer… curcumin can supress tumour initiation, promotion and metastases.”
In fact, curcumin targets ten causative factors involved in cancer development. Disrupting any one of these factors gives you a good chance of preventing cancer; disrupting several provides even greater protection, including the prevention of DNA damage.
Research has shown that by blocking the inflammatory principal molecule nuclear factor-kappaB (or NF-kB), curcumin blunts cancer-causing inflammation, slashing levels of inflammatory cytokines throughout the body. Curcumin also interferes with production of dangerous advanced glycation end products that trigger inflammation which can lead to cancerous mutation.
Curcumin alters cellular signalling pathways to enhance healthy control over cellular replication, helping to stop uncontrolled proliferation of fresh tumour tissue. It promotes apoptosis (programmed cell death) in rapidly reproducing cancer cells without affecting healthy tissue and restrains tumour growth. In addition, curcumin regulates tumour suppressor pathways and triggers death in tumour tissue, thereby increasing the death of cancer cells.
Curcumin has also been shown to interfere with tumour invasiveness, and also helps to starve tumours of their vital blood supply, and it can oppose many of the processes that permit metastases to spread. These multi-targeted actions are central to curcumin’s ability to block various forms of cancer before they manifest.
At a glance: Curcumin’s multi-targeted anti-cancer effects
Life Extension, Report: How curcumin protects against cancer
Curcumin: The 21st century cure by Jan McBarron, M.D. N.D.
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Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumours and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010 Oct; 62(7):919-30.
Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy M. Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal. Hum Exp Toxicol. 2010 Jun;29(6):513-24.
Bachmeier BE, Killian P, Pfeffer U, Nerlich AG. Novel aspects for the application of curcumin in chemoprevention of various cancers. Front Biosci (Schol Ed). 2010 Jan 1;2:697-717.
Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K. The promise of slow down ageing may come from curcumin. Curr Pharm Des. 2010;16(7):884-92.
Sajithlal GB, Chithra P, Chandrakasan G. Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats. Biochem Pharmacol. 1998 Dec 15;56(12):1607-14.
Curegarden represents a dream. A dream of sharing a happier, healthier body and quality of life with the use of nature's best ingredients. Botanics, when extracted for their bioactive compounds, offer a most effective approach to improving well-being and quality of life. It is based on the belief that botanicals of the highest quality would have a positive effect — without any negative side effects — on people's health. Over the years,we have seen and experienced personally the wonderful benefits of these high quality botanical products and are delighted to share them with others.
Arjuna Natural Extracts Ltd is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for over two decades. With customers in around 40 countries, the company has close to 50 patents to its credit of which majority are commercialized globally. The company has R&D tie ups with international universities from Australia, US and Japan. The highly advanced R&D unit at Arjuna is a complete research facility for phytochemistry, pharmacokinetics, formulation and development, pre-clinical and clinical studies.
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